Induced pluripotent stem cells (iPSCs) are a pluripotent cell type that can be directly generated from a somatic cell. These cells are relatively abundant, can be easily procured from patients, and can differentiate to every other cell type in the body. As these cells are generated from patients, they can also be used to study and develop therapeutics for genetic diseases. The Bao Lab is utilizes CRISPR/Cas9 gene editing in iPSCs from patients with cystic fibrosis (CF) to study the cellular impact of specific CF mutations, investigate CF complications, allow for in vitro screening of CF therapeutics, and determine the potential of autologous gene-corrected iPSCs as a cell therapy for CF.